Tirzepatide vs. Semaglutide
Both are GLP-1 receptor agonists prescribed for weight management, but they work differently and have shown different average results in clinical trials. Here’s an honest, side-by-side comparison.
| Tirzepatide | Semaglutide | |
|---|---|---|
| Drug class | Dual GLP-1 / GIP receptor agonist | GLP-1 receptor agonist |
| Brand names | Mounjaro, Zepbound | Ozempic, Wegovy, Rybelsus |
| Average weight loss in trials* | Up to ~20.9% (SURMOUNT-1) | Up to ~14.9% (STEP 1) |
| Dosing | Weekly injection | Weekly injection or daily tablet |
| Orik first month (compounded) | $229 | $179 |
| Orik ongoing monthly | $349/mo | $299/mo |
*Trial results come from separate studies (SURMOUNT-1 for tirzepatide, STEP 1 for semaglutide), not a head-to-head comparison. Individual results vary.
Source: SURMOUNT-1 trial (tirzepatide), NEJM 2022
Frequently asked questions
Is tirzepatide better than semaglutide?+
In separate clinical trials, tirzepatide produced larger average weight reductions, but the two have not been compared head-to-head for weight loss. The right choice depends on your health profile, tolerance, and goals, which a licensed provider will assess.
Which one is cheaper?+
At Orik, compounded semaglutide starts lower ($179 first month / $299 ongoing) than compounded tirzepatide ($229 first month / $349 ongoing).
Can I switch between them?+
Some patients change therapies based on tolerance or results. Any change is a clinical decision made with your provider.
Not sure which is right for you?
A licensed provider reviews your health profile and recommends an appropriate option. No insurance required.
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